2nd letter from me: Ons 24/4/2019
Velma,
I am happy for you. The whole experience is roller coaster. Whew, you made it! Good for you!

Thank you for responding. I appreciate that.

I am interested in fascia. I understand the endothetial tissue of the blood vessels release the gas Nitric Oxide naturally. When flavonoids are introduced, the production of NO is higher. Because fascia has contractile properties (myofibroblasts) like the smooth muscle of blood vessels, this makes me wonder about increased Nitric Oxide for Parkinson’s patients.

I appreciate your willingness to be curious. I hope the following link to Professor Spencer’s lab in the UK interests you as well.

Thank you from Sweden.
Allissa 🙂

https://www.reading.ac.uk/food/about/staff/j-p-e-spencer.aspx
Name: Professor Jeremy Spencer

A major output from the group has been to help define the paradigm-changing concept of how flavonoids and other polyphenols act via non-antioxidant mechanisms of action in vivo to mediate physiologically/clinically significant benefits on human brain and vascular function. His group have defined how a number of flavonoids/polyphenols and their metabolites exert specific interactions within ERK and PI3 kinase/Akt signalling pathways, leading to increases in the expression of neuroprotective and neuromodulatory proteins and an increase in the number of, and strength of, connections between neurons. Furthermore, they have detailed effects on the vascular system, which may lead to enhancements in cognitive performance through increased brain blood flow and an ability to initiate neurogenesis in the hippocampus.

Answered: April 17, 2019
Hello Allissa,
And thank you for your email. The defence went well – I passed (still waiting to get the diploma through all the bureaucracy), and it was a fascinating scientific discussion overall, just like your question!

I must admit I don’t know anything at all about the relationship of Prevotellaceae and nitric oxide. I have primarily focused on gut microbiota analyses, and a quick literature search of Prevotella and NO seems to mainly give hits related to oral microbiota. The oral species and strains tend to be different from the ones in the gut, so it’s difficult to know how similar their metabolism etc would be. Overall, what the gut Prevotella species are actually doing seems quite unclear to me based on the literature I’ve found so far, so there’s a lot of research to be done regarding that. But I think I will try to look more into the Prevotella and NO literature in the future, since this is something I haven’t read about at all. So, unfortunately I don’t really have an answer for you, but it’s an interesting question, so thank you again!

Best regards,
Velma

———-
Velma T. E. Aho, MSc, BA, Doctoral student
DNA sequencing and genomics lab
Institute of Biotechnology
P.O. Box 56 (Viikinkaari 5)
00014 University of Helsinki
Finland

1st email: April 11, 2019
Ms Velma Aho,

I understand from the University of Helsinki website you are in the doctoral program and recently defended your dissertation. I hope it went well for you.

Could you help me? I am curious, is there is a relationship between the Prevotellaceae family and in vivo production of Nitric Oxide?

Many thank yous,
Allissa living in Sweden

Resources
1) Pa­tients with Par­kin­son’s dis­ease have clear changes in their gut mi­cro­bi­ota
25.3.2019
https://www.helsinki.fi/en/news/life-science-news/patients-with-parkinsons-disease-have-clear-changes-in-their-gut-microbiota

2) http://www.gutmicrobiotaforhealth.com/en/gut-microbiota-in-parkinsons-disease
27 DEC 2014 Filip Scheperjans