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British Fascial Symposium 2018

v40 2019 “Researcher at Ulm University and Airplanes.”

Electronic Writing Campaign 2019 Posted on Sat, November 23, 2019 14:21:28

Electronic letter writing campaign September 30 2019
NO RESPONSE as of posting on UggleBo Blog – November 23, 2019
Rewritten 23 nov 2019 to be more eloquent.
I will send him in Paper writing campaign to follow shortly.

Ralf Vogt MSc, DO – Fascia Research Group at Ulm University
Engineer aircraft and spacecraft techonoliges.
Author: Fascia in the Osteopathic Field, chapter 48 (2017)”

Dear Ralf Vogt,

I have been a massage therapist since 2002.  The explanations of the muscular system do not answer my question as to why one client can turn from prone to supine with ease while another client uses an extreme amount of energy to do the same action.

I was reading “Fascia in the Osteopathic Field 2017” to find you have Chapter 48 “Fascial treatment of the vascular system”.  The book also highlights you are an engineer with aircraft and spacecraft technologies.  This is the reason I am writing to you.  

I am eager for insight, but I do not have a background in science, so forgive the plain language.

I appreciate your time.  I am curious.  If this reaches your curiosity as well, great.  If it does not, please let me know not to bother you again. (altered from original email sent 30-sept-2019).

All my best in your research,
Allissa from Iowa, Living in Sweden

Part 1-
In aircraft engines, baffles are designed to regulate temperature.  The location of these baffles is critical as well as their integrity. Is this assumption correct?  If baffles crack, they could leak. The result, the engine temperature may increase.  As I see it, the integrity of the baffles are essential for proper function and flow (air in the case of an engine).

When I think of air flow, sound comes to mind.  There are acoustic baffles. Wall panels or hanging ceiling panels absorb sound waves so the din of private conversations can stay at a reasonable level. Without these acoustic baffles re-directing sound waves, the environment or echo of a gymnasium or cafeteria would have a high reverberation.

Often when I pick up a book on fascia, histology and pathology are discussed.  But the Integrity of the Fascia seems to be important, especially for those whose who cannot regulate temperature (Raynaud’s Disease, a viral or bacterial infection).  When reverberation occurs due to fascial integrity loss, leaks happen, I believe.   The Ebola virus compromises the interfaces of separating tubes on a macroscale. Fluids flow into areas where they are not supposed to.

Fascia is observed as long continuous tubes. Here lies, a is similarity of a human and a tree. The xylem of a tree, defies gravity as fluid moves upwards due to compressive forces. Alternations between loose and dense connective tissue, may be, a way of fluids to move against gravity. But could the dis-Integrity or fascial membranes be the cause as to why some clients cannot move with ease?  

A leak or crack occurs, and the mechanical stress changes therefore transduction is also altered.  The Somatosensory system, Interoception or Haptics no longer function efficiently.

Most of the time the body works without problems, but the older someone is or after a viral / bacterial infection, the body has trouble recovering (Dysautonomia, POTS Syndrome, ME and CFS). Even a healthy teenager could get a viral infection which causes body wide issues, Ian Waterman for example. He lost his ability to Propriocept after an illness. The common cold virus takes away ones center of gravity and balance. Are these the result of Fascia Dis-Integrity?

Collagen is water repelling, hydrophobic. Hyaluronan is water loving, hydrophillic. In loose connective tissue, the GAGs and PGs are opposites.  

These opposite forces encourage fluid and nutrients to flow despite gravity, as water is a diamagnet, repelling.  When a leak or a crack happens in an engine baffle, the baffle is a material without an electric charge, but in fascia there is a bioelectric potential which changes as well.  

  • Would dis-Integrity cause ……
  • local inflammation?  
  • transduction signaling problems (phototransduction, mechanotransduction of the somasensory system – Poor Introception)?
  • MORE importantly-
  • Would Human Haptics be impeded by this lack of Fascia Integrity?

Part 2-
As an engineer, are there any similarities to passive stabilizers in the human?

After watching the YouTube video of passive roll damping system, FLUME SYSTEM, used by Hoppe-Marine GmbH in Germany, can you tell me if, there is anything like passive stabilizers used in ships to help them balance also used in the human?

I liken this balance phenomena like the Integrity of Fascia = movement in an effortless manner vs DisIntegrity of Fascia = one cannot turn over on my massage table – movement is full of effort. Would you agree or disagree?

FLUME Stabilization System

https://www.youtube.com/watch?v=dtEJamVv05M



v30 2019 “Cancer and Microbes.”

Electronic Writing Campaign 2019 - Fascia Posted on Sat, November 23, 2019 14:00:54

Peter was kind enough to respond to my email within 7 minutes. He apologized for no clear answers to give me. Microbes and the fascia/conduit system to propagate tissue is outside of his area of expertise.

He suggested need for tissue samples and perform 3D microscopy to address questions scientifically.

Original email dated v30 fredag den 26 juli 2019

To: Peter Friedl European Onocology researcher
Re: Cancer “Stop Signals”, perhaps a mycologist could help. Fascia is our Stroma.

Lieve Mijnheer Friedl,
I have read some of your Research Papers with Stephanie Alexander.  Thank you for being in Bruce Schonfeld’s documentary “The Secret Life of Fascia, part 1”.  Sue Hitzmann spoke very highly of your work and lecture at The 5th Fascial Research Congress in Berlin last November.

Dr. Tom Findley spoke in 2015 at the Joint Conference on Acupuncture, Oncology and Fascia.  He said, looking for lost keys under the light will not lead to finding the keys.  We look under the light because we can see better, but the keys are somewhere else.

In the same theme, I am writing to you.  You are the researcher / scientist, I am the curious student of fascia and microbes.  If one wants to find the “Stop Signals”, could you please speak to someone who knows about small communities – such as a mycologist, a biologist specializing in mycology, about the nano-environment?

The Extra Cellular Fluid and Stroma is where microbes live, thrive and communicate.  Perhaps a mycologist from Micropia can shed light where there is darkness on cellular behavior as well as microbial behavior.  

Thank you kindly for reading.
Allissa from Iowa, Living in Sweden

CELL, Volume 147, Issue 5, 23 November 2011, Pages 992-1009
“Cancer Invasion and the Microenvironment: Plasticity and Reciprocity”
Cancer cells recapitulate the types and mechanisms of migration used by normal, nontumor cells. They activate the same machineries for changing shape, generating force, and remodeling ECM (Friedl, 2004) as normal cells, but neoplastic cells lack physiological  ‘‘stop  signals’’  immobilizing and anchoring the cells (Cox et al., 2001), which arguably perpetuates neoplastic cell migration.

https://www.sciencedirect.com/science/article/pii/S0092867411013547

STROMA – thought from Allissa
Humans are advanced organisms of Stroma like the mycelia of a forest.  Sclerotic fungi vs soft fungi is stroma.  Humans are made up of wandering cells, fixed cells, and fibroblastic cells with different tissue types (loose and dense irregular) with fluid and fibers in between.

A mycologist knows about the forest environment where fungi live, why not use their knowledge and apply it to the human body?

The Naked Scientist discussed Schwann cells in interviews with Professor Alison Lloyd who works at the University College London.  Schwann Cells are Neuroglia which are present in the periphery.  Professor Lloyd states peripheral nerve cell damage can be healed by Schwann cells.  The healing brings back sensation and movement.  

Schwann cells are able to migrate out of a severed nerve across a bridge of tissue.  As they travel, they take the axons they are attached to with them.  Like dragging a broken foot to the hospital, one limp at a time.  Schwann cells NEED a track or a bridge of tissue to travel along.  In Professor Lloyds example, a blood vessel is the surface Schwann cells use as a bridge.

The Stroma type in Professor Lloyd’s example is a blood vessel.  Fascia must be another conduit.   Fascia can be the surface Schwann cells use as a Track or a Bridge for healthy stroma or for cancer stroma which thinks it is unhealed.  

Understanding cellular behavior changes as well as microbial behavior comes from bringing other professions into the cancer lab.  Perhaps a mycologist can be the person to shed light on the communication of microbes such as the mycelia of a forest.

Nerve repair provides clue to cancer spread
26 September 2010


It’s this ephrin signalling that tells the Schwann cells to organise themselves into tracks, as directed by the fibroblasts, so the nerves can regrow, a bit like traffic police using special hand signals to direct cars into different queues on a road.
And, importantly, the scientists found that switching off ephrin signalling meant that Schwann cells couldn’t repair nerve damage, proving that it’s a fundamental part of the process. So these findings tell us something important about nerve repair, which will be useful for researchers working on techniques such as nerve grafts, which could repair damaged nerves after accidents or surgery.
So how is this linked to cancer?
Professor Lloyd thinks that cancer cells may be acting a bit like an unhealed wound, hijacking the signals that normally repair nerves.

http:// https://www.thenakedscientists.com/articles/science-news/nerve-repair-provides-clue-cancer-spread

Scientists re-grow damaged nerves 
17 August 2015


Professor Alison Lloyd – “And so, I think what our work suggests is that what you want to do is to mimic the real bridge. So, you want to maybe make tubes with blood vessels, either blood vessels themselves or surfaces that mimic what it is about blood vessels that provide a surface for the Schwann cells. But I think it has broader implications for other diseases as well. The way that certain cancers spread within the body, these cells are moving along the surface of other cells. It has been observed that cells such as melanomas and gliomas for example.”

https://www.thenakedscientists.com/articles/interviews/scientists-re-grow-damaged-nerves

“They’re brain tumours and they’re very, very invasive. That’s the major problem with them but they also seem to be migrating along the surface of blood vessels. So, it’s possible that when these cancer cells are moving and they’re moving along blood vessels, they’re using the same mechanisms that you see following an injury and they’re co-opting this type of behaviour in order to spread. And so again, if we can understand that better then possibly, we can understand better how tumours spread and then maybe do something about it.”

https://www.thenakedscientists.com/articles/interviews/scientists-re-grow-damaged-nerves

Panel Discussion, OSHER Joint Conference – November 2015
OSHER Center for Integrative Medicine

https://www.youtube.com/watch?v=_hHUjmHXIi8
@36:00 – 37:10 – Dr. Tom Findley
Professor of Physical Medicine and Rehabilitation, Rutgers, New Jersey Medical School, VA New Jersey Health Care System

“Looking for keys under the light….…muscle does not get cancer metastasis very much. So why is it so resistant? Muscle actually makes a small molecular product that you can filter out of a muscle cell culture which will kill tumor cells – so activating muscle may have protective effects elsewhere in the body not just on muscle….”

http:// https://www.youtube.com/watch?v=_hHUjmHXIi8



v28 2019 “Immunologist meet Chef.”

Electronic Writing Campaign 2019 Posted on Sat, November 23, 2019 13:48:49

Electronic letter writing campaign July 14 2019

Jeppe Madura Larsen, Researcher Denmark’s Technical Institute – Research group for Food Allergy

David Zilber is Director of Fermentation at Noma. Author: The Noma Guide to Fermentation

Dear Mr Larsen from Denmark meet David Zilber from Denmark (1).
I am writing to you based on research and questions into pain, Parkinson’s, and dysbiosis.  I wrote to David Zilber on Facebook as well about you. I believe you two together could do good things together. 

David Zilber has a gift that I think could transform medicine.  Next to David Bouley, Mr Zilber is a young equal. 

Scientists are finding low levels of Prevotella copri in fibromyalgia sufferers (2) also research from Helsinki has shown Parkinsons Patients have lower Prevotella family in their gut microbiome (3). 

Strangely, your Immunology Paper 2017 finds Prevotella can be inflammatory and bad – yet at the same time- good for the lungs of asthma and COPD sufferers. “The immune response to Prevotella bacteria in chronic inflammatory disease”

As if Prevotella has a MultiplePersonality Disorder. I find this multiple personality…… odd. Don’t you?

Sarkis Mazmanian has indicated Short Chain Fatty Acids can be anti-inflammatory in the gut, yet pro-inflammatory in the brain (4). In May 2019, his lab at Caltech produced research linking the gut microbiome of humans with Autistic-like behavior in mice. (5)

How is this possible?  

Would you consider crossing the border of medical science with the culinary arts? Would you collaborate with a chef?

Is it possible these microbes need to be in teams or pairs in order to be commensal instead of pathobionts?

Food is our medicine.  Food can be paired up; therefore, protective. Unlike pharmaceuticals which target specific receptors, food has a multitude action plans.

Thank you for reading,
Allissa Harter from Iowa, Living in 🇸🇪 Sweden 

Resources:
David Zilber on Science Friday – July 12, 2019
“World-Class Tips For The Home Fermenter”

The following is an excerpt of The Noma Guide to Fermentation by René Redzepi and David Zilber.

“There are thousands of products of fermentation, from beer and wine to cheese to kimchi to soy sauce. They’re all dramatically different creations, of course, but they’re unified by the same basic process. Microbes—bacteria, molds, yeasts, or a combination thereof—break down or convert the molecules in food, producing new flavors as a result. Take lacto-fermented pickles, for instance, where bacteria consume sugar and generate lactic acid, souring the vegetables and the brine in which they sit, simultaneously preserving them and rendering them more delicious. Cascades of secondary reactions contribute layers of flavors and aromas that didn’t exist in the original, unfermented product. The best ferments still retain much of their original character, whether that’s a touch of residual sweetness in a carrot vinegar or the floral perfume of wild roses in a rose kombucha, while simultaneously being transformed into something entirely new.”

https://www.sciencefriday.com/segments/world-class-tips-for-the-home-fermenter/

2) “First Evidence’ Links Gut Bacteria, Fibromyalgia”. 
The findings were published online June 18 2019 in the Journal Pain

3) Parkinson’s research – University of Helsinki – Filip Scheperjans MD, PhD and Velma T.E.Aho MSc, BA

4) “Proving causality in the gut brain axis”-  by Sarkis Mazmanian, Caltech

https://m.youtube.com/watch?v=owj2gkomv2s

5) Sarkis Mazmanian Lab
ARTICLE VOLUME 177, ISSUE 6, P1600-1618.E17
MAY 30, 2019
“Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice”

https://www.cell.com/cell/fulltext/S0092-8674(19)30502-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867419305021%3Fshowall%3Dtrue

Article about study: Now researchers show the collection of bacteria and other microorganisms in the gut known as the microbiome contributes to autism-like behaviors such as decreased social interactions and repetitive actions in mice. The discovery means that new therapies for autism based on the microbiome might be possible.

“While all studies in mice need to be validated in humans, our discoveries suggest that microbiome-based treatments may be effective in ASD,” said Sarkis Mazmanian, a microbiologist at CalTech who led the new research. 



v28 2019 to Prof Olivier Piguet

BFS Lecture Posted on Fri, July 12, 2019 20:36:12

reply kl 13.51 fredag 12-7-2019

Thank you for your message. I am away until 18 July 2019 with limited access to emails during this time.

Please feel free to re-send your email after this date.
Thank you

To Professor Olivier Piguet – The Olfactory Sense
– emailed Fredag 12-7-2019

PROFESSOR OLIVIER PIGUET
https://sydney.edu.au/science/people/olivier.piguet.php
Member of the Brain and Mind Centre
Member of the Charles Perkins Centre
The University of Sydney

Biographical details
Prof Piguet is an NHMRC Senior Research Fellow and Professor of Clinical Neuropsychology. He is the co-director of FRONTIER, the frontotemporal dementia clinical research group and the director of the Memory Program of the ARC Centre of Excellence in Cognition and its Disorders.

Good Day Professor Piguet,
I watched you on a Netflix show, “Ask the Doctor”, episode “The Senses”, season 1.

I have reason to believe the sense of smell is diminished in Parkinson’s Disease and other neurological conditions as a result of dysbiosis. Joy Milne can smell Parkinson’s which leads me to believe, like a case of Strep Throat which can be smelled from an over abundance of Streptococcus pyogenes, a dysbiosis exists in PD patients.

An out of balance microbial soup allows an overgrowth of one or more, therefore, a diminished population of another. If the diminished population can be supported or re-established symptoms of the disease (tremors, anosmia, cognitive decline, breathing difficulties) could be managed better. There is a possibility that perhaps the congruence of dysbiosis leads to mis-folding of Beta Amyloid Peptides, Tau Proteins or Alpha-synuclein Protein 1, Could these tangled accumulations NOT exist if dysbiosis were treated?

It is well known drugs interact with body function. Morphine binds to an opiate receptor to have its effect. When the opiate receptor is located on sphincters in the lower digestive system, the sphincters relax and a side effect occurs – constipation.

Nature
ran an article in March 2018 2, how non-antibiotic pharmaceuticals could affect the gut microbiome. The Microbiome is not only in the gut, it is on the skin, in the mouth, in epithelial tissue and in the nasal passages as well. The sense of smell is highly relevant to the communities of microbes within the olfactory system. An early warning sign of PD, is the loss of the sense of smell.

Prevotella
species help the breakdown of protein and carbohydrate foods in the rumen of cattle and sheep. Studies have shown patients with Parkinson’s disease have less bacteria of the Prevotellaceae family in their gut than control subjects 3. Why? We don’t know.

When humans eat flavonoids, this type of polyphenol is beneficial to the human brain and vascular function.4 Before the human body absorbs a flavonoid, intestinal enzymes or colonic microflora MUST hydrolyzed them 5. If the colonic microflora is missing, the health benefits and vascular protections are missing.

The roots of a legume plant secrete flavonoids to help gram negative, motile, non-sporulating rods of diazotrophic bacteria known as Rhizobia have a symbiotic relationship and fix nitrogen for the plant to have in a usable form. 6

Is there a possibility, the Nitric Oxide, humans need is regulated by a microorganism like in the legume plant? Perhaps the lack of this microbe in humans stiffens not only the blood vessels but the human fascial system, whereby making neurotransmission and neuromodulation inept. Cycling, Boxing, Singing and Dancing all promote more Nitric Oxide production in vivo.
If I were a protein, overtime, I would mis-fold and mis-behave, under these circumstances, without the proper balance of microbes.

I leave you with excerpts from an article written by Miro Mannino. There have been many whom have written about the Island of Guam and lytico-bodig disease like Oliver Sacks.

All my best for your research. Hope you can used some of mine.
Allissa Harter from Iowa, Living in Sweden

Long studied, now disappearing disease (excerpts only)
https://www.guampedia.com/lytico-bodig-on-guam/
by Miro Mannino

Lytico-bodig is the local name for a complex of neurological diseases (or diseases that affect the nervous system) on Guam that resembles amyotrophic lateral sclerosis (ALS or Lou Gerhig’s disease), Parkinsonism-Dementia (PD) and possibly Alzheimer’s disease.

Although lytico-bodig are worded together, they actually represent two different diseases. The term “lytico” comes from the Spanish word paralytico which means weakness. “Bodig” comes from the Spanish word bodega, or warehouse. Lytico patients have ALS symptoms, while patients with Bodig have symptoms that resemble PD.

Because of its occurrence in a relatively unique and isolated population, lytico-bodig has been widely studied by various groups of researchers in the hopes of finding its cause and possible cures.

Now known formally as ALS-PD complex of Guam (ALS-PDC), its prevalence in the 1950s and 1960s brought a sense of immediacy to working on Guam as patients passed away from the disease. The major research efforts sought to answer the question of whether lytico-bodig is a genetic or hereditary disease, or one caused by some environmental factor or factors? Although numerous theories were brought forward, there is still no definitive set of causes or cures. With advances in medical technology, strides have been made toward understanding lytico-bodig clinically, however, only few have studied its social or cultural impact on the Chamorro people. Although reports of neurological disease resembling lytico-bodig among the Chamorros occurred as far back as the early 1800s, formal study of the disease would not take place until more than a century later.

At its peak in the 1950s, lytico-bodig became the leading cause of death for Chamorros, affecting some 420 per 100,000 Chamorros, at a ratio of 2:1 males to females. ALS was seen more in Chamorros, while PD was seen in both Chamorro and Filipino natives. According to Chris Plato, et al., the incidence of ALS peaked from 1950-1954 in both males and females, but by the late 1950s, the incidence of ALS began to decline. Also, the incidence of PDC in males peaked from 1960 to 1964, and then declined steadily until 1980. The incidence of PDC in females peaked in 1970 to 1974, then rapidly declined in the early 1980s.

Another symptom which seems to be associated with ALS/PDC is linear retinal epitheliopathy, which is a disorder of the eye. The retinal epithelium is the pigmented layer of the retina at the back of the eye that anchors photoreceptors, or the cells that sense light and help with vision. There are no symptoms except for unusual tracks that appear in the retinal layer, but it seems to appear in half of Guamanian Chamorros with ALS and PDC and to precede the onset of the disease.

Cycads (fadang)
Probably the most well-known proposed cause of lytico-bodig involves neurotoxins in cycad seeds. In the 1960s, early researchers Leonard Kurland and Donald Mulder postulated that poisons in cycad seeds, ingested over time, possibly caused the disease on Guam. Unlike other Pacific islands, the Chamorros on Guam would leech the seeds of the false sago palm (Cycas micronesica, or fadang in Chamorro) to remove the poisons and then ground them into flour for baking.

In the early 2000s, the cycad toxin theory was brought up again with Paul Cox and Oliver Sacks who observed a decline in lytico-bodig that paralleled a decline in the fruit bat population on Guam. They proposed that while cycad processed into flour was not toxic enough to produce lytico-bodig, there may be other elements in the Chamorro diet that could magnify the effects of the neurotoxin. Eating fruit bat (Pteopus ariannusmariannus, or fanihi in Chamorro), for example, a local delicacy, might contribute to the possibility of the disease. The scientists suggested that fruit bats that eat the cycad accumulate the toxins in their tissues but may not themselves be affected by the toxins.

However, if people ate enough of the fruit bats over the course of their lifetime (perhaps beginning in childhood), the toxins could accumulate in their bodies and eventually cause the disease. Cox also suggested that the presence of cyanobacteria in cycads which could produce BMAA naturally, may also be considered a possible cause. Cox and his colleagues also reported that BMAA was found in ALS and PD patients on Guam.


RESOURCES 1-6:

1) https://ghr.nlm.nih.gov/gene/SNCA
It is unclear how alterations in the SNCA gene cause Parkinson disease. This condition involves the selective death or impairment of neurons that produce dopamine. Misfolded or excess alpha-synuclein proteins may cluster together to form Lewy bodies and impair the function of these neurons in specific regions of the brain. Lewy bodies may disrupt the regulation of dopamine, which allows dopamine to accumulate to toxic levels and eventually kill neurons.

2) Nature volume 555, pages 623–628 (29 March 2018)
“Extensive impact of non-antibiotic drugs on human gut bacteria”
Lisa Maier, Mihaela Pruteanu, Michael Kuhn, Georg Zeller, Anja Telzerow, Exene Erin Anderson, Ana Rita Brochado, Keith Conrad Fernandez, Hitomi Dose, Hirotada Mori, Kiran Raosaheb Patil, Peer Bork & Athanasios Typas

3) Pa­tients with Par­kin­son’s dis­ease have clear changes in their gut mi­cro­bi­ota
25.3.2019
https://www.helsinki.fi/en/news/life-science-news/patients-with-parkinsons-disease-have-clear-changes-in-their-gut-microbiota

A study carried out at the University of Helsinki indicates that microbes in the gut and mouth could provide new perspectives on the onset of Parkinson’s disease, particularly as they have long been suspected to play a part in the disease process.

Recently, microbial inhabitants of the human body have been connected to several health problems, including Parkinson’s disease and other neurological diseases.

In her doctoral dissertation, Velma Aho investigated the potential associations of Parkinson’s disease and human microbiota in the mouth, nose and gut, and examined the tools used to compare their abundance. Aho’s findings supported an observation according to which patients with Parkinson’s disease have less bacteria of the Prevotellaceae family in their gut than control subjects.

Prevotella
species are among the most numerous microbes culturable from the rumen and hind gut of cattle and sheep, where they help the breakdown of protein and carbohydrate foods.

my Letter to Velma Aho. She answered April 17, 2019
“I must admit I don’t know anything at all about the relationship of Prevotellaceae and nitric oxide. I have primarily focused on gut microbiota analyses, and a quick literature search of Prevotella and NO seems to mainly give hits related to oral microbiota. The oral species and strains tend to be different from the ones in the gut, so it’s difficult to know how similar their metabolism etc would be. Overall, what the gut Prevotella species are actually doing seems quite unclear to me based on the literature I’ve found so far, so there’s a lot of research to be done regarding that. But I think I will try to look more into the Prevotella and NO literature in the future, since this is something I haven’t read about at all. So, unfortunately I don’t really have an answer for you, but it’s an interesting question, so thank you again!”

4) Professor Jeremy Spencer
https://www.reading.ac.uk/food/about/staff/j-p-e-spencer.aspx

A major output from the group has been to help define the paradigm-changing concept of how flavonoids and other polyphenols act via non-antioxidant mechanisms of action in vivo to mediate bphysiologically/clinically significant benefits on human brain and vascular function. His group have defined how a number of flavonoids/polyphenols and their metabolites exert specific interactions within ERK and PI3 kinase/Akt signalling pathways, leading to increases in the expression of neuroprotective and neuromodulatory proteins and an increase in the number of, and strength of, connections between neurons. Furthermore, they have detailed effects on the vascular system, which may lead to enhancements in cognitive performance through increased brain blood flow and an ability to initiate neurogenesis in the hippocampus.

5) Oxid Med Cell Longev. 2009 Nov-Dec; 2(5): 270–278.
doi: 10.4161/oxim.2.5.9498
PMCID: PMC2835915
PMID: 20716914
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835915/

Plant polyphenols as dietary antioxidants in human health and disease
Kanti Bhooshan Pandey and Syed Ibrahim Rizvi
Department of Biochemistry; University of Allahabad; Allahabad, India
Corresponding author.
Correspondence to: Syed Ibrahim Rizvi; Email: moc.liamg@ivziris

6) Wikipedia….https://en.wikipedia.org/wiki/Diazotroph
Diazotrophs are bacteria and archaea that fix atmospheric nitrogen gas into a more usable form such as ammonia. Cyanobacteria—there are also symbiotic cyanobacteria. Some associate with fungi as lichens, with liverworts, with a fern, and with a cycad.[8]



V26 2019 Joanne Avison / John Sharkey

BFS Lecture Posted on Fri, July 12, 2019 20:24:26

v26 ons den 26 juni 2019 kl 12.31

Dear Joanne Avison and John Sharkey,
I have been listening to you since the NTC symposium prior to the 2016 BFS. From chocolate to bones which float, your ideas have been bending my ideas.

I would like to take the Fascia Tensegrity Course starting in September 2019. I would appreciate your help to dive into a subject more, “The Placebo Effect” per John Sharkey’s brilliant segway about the Ligament of Berry in the throat causing an “embarrassment of the heart”.

I watched Michael Mosley’s Placebo Experiment on Swedish television. Fascia may hold more of a key as to the HOW Dr. Andrew Carr’s shoulder placebo experiment had a positive effect on the “real” and “placebo” shoulder operations.

Also, and excellent study In 1959, Dr. Leonard Cobb reduced Angina Pectoralis with a sham surgery. It was thought at the time, chest pain was reduced by real surgery, ligation of the internal mammary artery. The real surgery was thought to increase coronary artery blood flow; therefore, reducing pain. Dr Cobb proved with his sham surgery, the reduction in pain was NOT due to ligation of the internal mammary artery. Chest pain reduction in his patients was called the Placebo Effect.

Mr. Sharkey and Ms Avison —- could be fascia responsible for this???

Is the Placebo Effect accurate? Could Fascia play a role? At the time in 1959, the rich sensory organ of fascia was discarded as an inert packing material. Only recently, with new technologies, have the advantages of the this connective tissue coming to the forefront of science.

The Placebo Effect was proven in Dr. Leonard Cobb’s Heart Ligation study. But given recent research into fascia, this must be reviewed. Also, Dr. Michael Mosley’s television program, “The Placebo Effect”, where the surgical intervention was just as effect as the sham surgery.

The Placebo Experiment: Can My Brain Cure My Body?
2018 Episode 8 of 15
Dr Michael Mosley attempts to cure real pain with fake pills in Britain’s largest ever trial to investigate the placebo effect. He also tries to experience it for himself.
https://www.bbc.co.uk/programmes/b0bmblb8

All my best,
Allissa from Iowa, Living in Sweden

PROFILE OF PROFESSOR ANDREW CARR
Andrew CarrChM DSc FRCS FMedSci
https://www.ndorms.ox.ac.uk/team/andrew-carr

HEAD OF DEPARTMENT
▪ Nuffield Professor of Orthopaedics
▪ Director of the Musculoskeletal BRC Theme
▪ Director of the Botnar Research Centre

Andy Carr is the Nuffield Professor of Orthopaedic Surgery at the University of Oxford. He is an inter-disciplinary researcher distinguished for evaluating and developing surgical implants and technologies and for his leadership in surgical and musculoskeletal research.



v25 2019 – Astronauts

BFS Lecture Posted on Fri, July 12, 2019 20:19:29

v25 söndag 23 juni 2019 kl 9.12 – matthew.cox@military.com
v25 söndag 23 juni 2019 kl 9.05 – sheryl.E.Baca@nasa.gov

A similar letter was also sent to NASA Astronaut contact: Sheryl Baca for Kate Rubins and Stephanie Wilson

Dear Mr Matthew Cox,
I read your article June 21, 2019 on Lt Col Anne McClain. She will return to Earth soon, so this email is relevant to her. I address her colleagues Kate Rubins and Stephanie Wilson as well per their education in microbiology and engineering.

Per your article, you wrote Lt.Col McClain worked on the following: “human immune-system response and antibody production and protein crystal formations to provide insight into Parkinson’s disease, the release states.” The human Fascial System has everything to do with Parkinson’s and the immune system, so my email is relevant to her work.

Would you be so kind as to help me get this email to Lt Col McClain? Please.
Thank you,

Allissa

Dear Awesome Astronauts Lt Col Anne McClain, Kate Rubins and Stephanie Wilson:
I am writing both of you because of your space travel experience and education in Immune System and PD, microbiology and flexible structures in space, respectively.

I am not sure of your interest in what I am about to say, but my interest is high. Therefore, I am inclined to get your thoughts/input?

Dr Karen Lloyd was on the TED stage discussing the complex criss-cross structures underneath our feet. “Tiny little fractures and empty spaces….filled with astronomical quantities of microbes.” Dr Lloyd runs Lloyd Lab (deep subsurface biosphere research) in the Department of Microbiology at the University of Tennessee.

This subsurface of Earth resembles our human body subsurface. This is what I want to introduce you to: fascia. I believe there is a way to help your bodies recover from space flight and microgravity.

The Fascial System of the human body has not been in textbooks as a System, but it is gaining traction. More scientists are researching the Interstitium and technologies are improving to view inside the living body at smaller scales.

As the human body comes back to Earth, it undergoes profound aging (eyes, muscles, bone) and neurological shifts. Perception of balance and coordination “in gravity” takes time to acclimate to after microgravity, despite a rigorous exercise routine.

Exercise helps to restore large scale hydration, electrolyte balance and health, but what about the smallest of the small criss-crosses of our sub-surface? Without gravity and pressure drive forces, fluid does not flow well. Minimal pressure driven forces cannot hydrate “Tiny little fractures and empty spaces….filled with astronomical quantities of microbes.”

Exercise helps but it is not the whole story. Mechanotransduction (compression, push/pull – coined from Donald Ingber) influences cell behavior, the telocytes and integrins necessary for communication at the smallest cell level.

The microbes within us also need mechanical forces in our tiniest of tiny spaces so communication (Quorum Sensing) may occur.

I see profound aging in my clients who are not old. Their body either has pain, their mind has brain fog, or their coordination is poor – not because of trauma. With loading and unloading tissues, their body regains suppleness (less stiff) due to the hydration of microvacuoles within the Fascial System.

We are a Biotensegrity structure. When under duress, the structure cannot find the center of gravity. Pressure driven forces cannot move fluid efficiently. Balance and coordination are no longer automatic, they have to be constantly considered in every movement. This is exhausting.

If you have time, or an interest, I encourage your next pre/post space flight to utilize Sue Hitzmann’s MELT Method along with the prescribed rigorous exercise regime in space.

Your colleague Anne McClain-whom is set to return Monday 6/24/2019-may find the MELT Method helps her body to reconnect to the mind and function as a unit, more profoundly and faster than without using the MELT Method.

If you are interested in being in contact with Sue Hitzmann directly. I will put you in contact with her right hand lady, Jaci Dygos.

Other resources regarding fascia and tensengrity models, since you both are grounded in science, are below.

Thank you to you all for being incredibly positive role models for my 12 year old daughter. She wants to study astronomy in Sweden.

Safe travels in the future to you both,
All my Best,
Allissa from Iowa, Living in Sweden.

Fascia Research Society
https://fasciaresearchsociety.org/

Dr Melody Swartz
https://www.sciencedirect.com/science/article/abs/pii/S0962892406003291
Trends in Cell Biology
Volume 17, Issue 1, January 2007, Pages 44-50
“A driving force for change: interstitial flow as a morphoregulator”

Dr Neil Theise – Liver pathologist
https://www.scientificamerican.com/article/meet-your-interstitium-a-newfound-organ/
https://www.scientificamerican.com/the-body/
Meet Your Interstitium, a Newfound “Organ”
These fluid-filled spaces were found in the body’s connective tissue
By Rachael Rettner, LiveScience on March 27, 2018

Dr. Carla Stecco- Italian orthopedic surgeon, research and author.
Dr. Carla Stecco has become an amazing force with her pioneering work in the cadaver lab. She has provided the realization of fascia no longer being discarded as refuse by the anatomist. Her book published 2015, Functional Atlas of the Human Fascial System, tells how the human body’s fascial system interplays with muscle, ligaments, and tendons as well as functions as an organ of sensory perception.

Excerpt from page 6 of her book, “Fibroblasts are the principal cell of the CT (connective tissue).” Fibroblasts main function is to maintain structural integrity of CT. They do this by secreting collagen, elastin, and complex carbohydrates of the ground substance into the Extra Cellular Matrix (ECM). Fibroblasts have a role in remodeling the matrix by degrading and synthesizing new fibers and proteins. “Fibroblastic proliferation and degradation is a normal occurrence in everyday mechanical loading such as walking, running, and most forms of movement. Collagen synthesis in the patellar tendon increases by nearly 100% as a result of just a single bout of acute exercise, and the effect is still evident 3 days later.”

Prof Dr. Carla Stecco spoke at the 5th Fascia Research Congress in Berlin, Germany November 2018 regarding a new receptor recently found, Endocannabinoid Receptor (CB2) in living tissue. This is found only in the fat cells of the subcutaneous and superficial fascia (not the deep layers of fascia). This receptor gives credence to soft tissue massage, as the receptor can stimulate the endorphin system.



v24 2019 to/from Doug Nelson

BFS Lecture Posted on Fri, July 12, 2019 18:26:57

replied email from Doug Nelson-
v24 sön den 16 juni 2019 kl 17.57

Hi Allissa,
Germany was wonderful, as was Denmark where we visited an exchange student and her family. I feel at home in the Nordic countries (no surprise there. . .)

May I publish your blood sugar case report on this page?
https://www.nmtmidwest.com/case-reports

Doug

email written to Doug Nelson-
v24 lör den 15 juni 2019 kl 11.04

Doug,
I always find when I have certain quandaries about my massage practice, I go back to PNMT classes and what I learned from you.

I saw recently you and Janet were in Germany. Were you able to check out the FASCIA exhibit from Gunther von Hagen’s Plastinarium in Berlin? https://fasciaresearchsociety.org/plastination

I listened to the Naked Scientists, Naked Neuroscience Podcast March 20, 2019 – “Uncovering Consciousness”. It made me know why I pursued a Blood Sugar Study when I was a massage therapist in Des Moines, Iowa. I thank you for being a wonderful guide and nurturing ideas.

All my Best
Allissa from Iowa, Living in Sweden 🙂

The elastic behind light bulb moments
with Leonard Mlodinow

“Human thinking can be put on a spectrum and at one end is logical, analytical, rational thought, that’s conscious thinking…..And at the other end of the thinking spectrum is elastic thinking, and that’s where that comes from. Elastic thinking isn’t about following rules it’s about making up the rules that you’ll follow later when you use the analytical thinking. It’s about how you see a situation, figure out what to ask about it and it’s about how you adapt and approach a novel situation or challenge.” by Leonard Mlodinow

Using Elastic Thinking in a small Blood Sugar Study
– alterations thru Massage Therapy albeit food intake

Feb 2014 – Sept 2014

I am not a scientist, but a massage therapist with a curious mind. It was often in Precision Neuromuscular Therapy continuing education classes in which instructor, Doug Nelson, would say, “We did a study on that.” There were data points on Adductor Magnus massage increasing ROM of hamstring length and flexibility benefits. There were data points on forward flexion increasing with simple massage therapy interventions. It was astounding to me, he and his office, and several other curious therapist embarked on case studies and research themselves.

When a client of mine (MCK1954) developed a condition of Type II Diabetes after years of healthy eating. He and I asked a lot of questions: Why? How?

MCK1954 should not have been on the diabetic chart given his lifestyle. An avid cyclist with his wife, he took the bus downtown to work so he could close his eyes and mediate, or look at other people and create stories of where they came from. His children often shunned the idea of having friends over for dinner, due to the menu and questions like, “What on earth are we eating?” Buckwheat pancakes with blueberry compote were often on the breakfast menu. Wheat grass shots were the first “go to” at the weekly Farmer’s Market outing on Saturday mornings.

Yet, MCK1954, was a career man with a stressful job at a large corporation.

Many health professionals told MCK1954 that his blood sugar was exclusively linked to diet. But he and I wondered if that was a medical myth. It did not make sense given his lifestyle.

Every time MCK1954 went home after massage, despite what he ate pre or post massage, his blood sugar had the most remarkable decrease. Could massage be helping MCK1954’s chronically high blood sugar levels to lower?

So MCK1954 and I did research “N of ONE”. Then more massage clients jumped on board.

METHOD:
An over the counter blood sugar testing device was found to calibrate well with MCK1954’s home blood sugar device. It was the standard monitoring device used throughout the study.

35 clients agreed to participate in the blood sugar test / massage experiment from Feb 2014-Sept 2014 and one sample taken June 2015.

Blood sugar was measured in 35 participants before their massage and directly after their massage, despite what they ate prior to massage. Three or more blood sugar levels pre and post massage were successfully measured in 33 participants. (#31 FJHalf1976 her last post measurement was taken June 2015, but the reading is on the Blood Sugar monitoring device. The device was moved to Sweden and it is in a box somewhere).

Results:
Values have not been statistically analyzed. But it is interesting how many people had a drop in blood sugar after massage, except the following outliers:

The case of #22 FHS1973, her 2nd testing. Her blood sugar was higher post massage than pre massage. Out of 3 samples taken, this was abnormal from her first and third sample. In the second sample, she had apprehension of going to a dentist appointment directly following the massage.

#3 MRP1961, 3rd sample out of 4 samples. Normally, he demonstrated a large decrease in blood sugar levels pre and post massage, except for the 3rd sample. MRP1961 was going on vacation directly after our massage. Upon arriving, he proudly boasted “I am not even taking the laptop on vacation!”.

I had a client with an opposite reaction.
#13 MJR1946 had consistent blood sugar levels and #1, #2, #3 samples. It was out of interest to test him on #4 pre and post massage. During the massage, I knew I would tell him I would be moving to Sweden in the very immediate future. His blood sugar raised on the 4th sample post massage.

Conclusion:
I understand this is not the most rigorous experiment on Blood Sugar and Massage. Many individuals told me I needed to measure blood sugar after fasting. Although, there are reasons for this, my reason for the experiment was to conclude: Could Massage Therapy allow the body to balance systems on its own?

The results speak for themselves and they are interesting.

It has been difficult to find someone whom could help crunch the numbers. I have contacted Universities and other scientists, alas no statistical data from the 35 participants has been calculated.

It is my conclusion, massage therapy does free the body to help homeostasis in most individuals with stressful lives.

In a Promotional advertisement from Abbott Labs*, the U.S. Food and Drug Administration’s approval of the FreeStyle® Libre for the 30.3 million Americans who have diabetes is the tip of the iceberg of monitoring fluid systems in the body. This measuring device monitors fluids in the periphery. My conclusion is massage therapy alters these fluid systems in the periphery, thus, helps to promote homeostasis throughout the body.

It is my conclusion, although diet may play a role in blood sugar levels, decreasing perceived stress thru massage therapy offers more health benefits than only diet control. Since this mini blood sugar study was completed, I have read information from Dr. Rangan Chatterjee (UK medical doctor), Alessandro Ferretti* nutritionist and researcher, and Dr. Brent A. Bauer* from Mayo Clinic USA all to point to the fact stress plays a significant a role in diabetes.

A PDF is included to see the 35 participants data.

Thank you for reading my Elastic Thinking Blood Sugar Study.
Allissa Harter from Iowa, Living in Sweden

* Visit
https://www.freestylelibre.us
The FreeStyle Libre system measures glucose levels through a small sensor — the size of two stacked quarters —applied to the back of your upper arm. It provides real-time glucose readings for up to 10 days, both day and night. The sensor can also read glucose levels through clothes, making testing discreet and convenient.

Studies show that FreeStyle Libre users who scan more frequently spend less time in hypoglycemia and experience improved average glucose levels. According to a study published in The Lancet, people using the FreeStyle Libre system spent 38 percent less time within hypoglycemia as compared with those who managed their glucose with traditional self monitoring glucose system.

Diabetes doesn’t have to control your life. It’s time to live freely.

* Alessandro Ferretti, nutritionist and researcher, who has spent years researching the effects of various stressors on the body by meticulously monitoring the heart rate variability (HRV) and blood sugar levels of both his clients and himself. He shares the fascinating findings of his research and explains that what causes stress on our bodies can be different for different individuals – one man’s medicine really can be another man’s poison – and the way we perceive an event is key. We also discuss the effect of shift work on our bodies, how type 2 diabetes is not just a dietary problem, how the wrong timing of meals can act as a significant stressor on the body and the impact of caffeine and insufficient sleep.

by Dr. Rangan Chatterjee / April 24, 2019
https://drchatterjee.com/personalising-your-health-with-alessandro-ferretti/

* 2016 INTERNATIONAL MASSAGE THERAPY RESEARCH CONFERENCE
KEYNOTE SPEAKER:
Brent A. Bauer, MD – Mayo Clinic
Massage Therapy at Mayo Clinic: Research Transforming Practice

AMTA presents IMTRC 2016
http://massagetherapyfoundation.org/massage-research/research-conferences/2016-international-massage-therapy-research-conference/2016-international-massage-therapy-research-conference-keynote-speakers/



v15v16 2019 Velma Aho

BFS Lecture Posted on Fri, July 12, 2019 18:04:37

2nd letter from me: Ons 24/4/2019
Velma,
I am happy for you. The whole experience is roller coaster. Whew, you made it! Good for you!

Thank you for responding. I appreciate that.

I am interested in fascia. I understand the endothetial tissue of the blood vessels release the gas Nitric Oxide naturally. When flavonoids are introduced, the production of NO is higher. Because fascia has contractile properties (myofibroblasts) like the smooth muscle of blood vessels, this makes me wonder about increased Nitric Oxide for Parkinson’s patients.

I appreciate your willingness to be curious. I hope the following link to Professor Spencer’s lab in the UK interests you as well.

Thank you from Sweden.
Allissa 🙂

https://www.reading.ac.uk/food/about/staff/j-p-e-spencer.aspx
Name: Professor Jeremy Spencer

A major output from the group has been to help define the paradigm-changing concept of how flavonoids and other polyphenols act via non-antioxidant mechanisms of action in vivo to mediate physiologically/clinically significant benefits on human brain and vascular function. His group have defined how a number of flavonoids/polyphenols and their metabolites exert specific interactions within ERK and PI3 kinase/Akt signalling pathways, leading to increases in the expression of neuroprotective and neuromodulatory proteins and an increase in the number of, and strength of, connections between neurons. Furthermore, they have detailed effects on the vascular system, which may lead to enhancements in cognitive performance through increased brain blood flow and an ability to initiate neurogenesis in the hippocampus.

Answered: April 17, 2019
Hello Allissa,
And thank you for your email. The defence went well – I passed (still waiting to get the diploma through all the bureaucracy), and it was a fascinating scientific discussion overall, just like your question!

I must admit I don’t know anything at all about the relationship of Prevotellaceae and nitric oxide. I have primarily focused on gut microbiota analyses, and a quick literature search of Prevotella and NO seems to mainly give hits related to oral microbiota. The oral species and strains tend to be different from the ones in the gut, so it’s difficult to know how similar their metabolism etc would be. Overall, what the gut Prevotella species are actually doing seems quite unclear to me based on the literature I’ve found so far, so there’s a lot of research to be done regarding that. But I think I will try to look more into the Prevotella and NO literature in the future, since this is something I haven’t read about at all. So, unfortunately I don’t really have an answer for you, but it’s an interesting question, so thank you again!

Best regards,
Velma

———-
Velma T. E. Aho, MSc, BA, Doctoral student
DNA sequencing and genomics lab
Institute of Biotechnology
P.O. Box 56 (Viikinkaari 5)
00014 University of Helsinki
Finland

1st email: April 11, 2019
Ms Velma Aho,

I understand from the University of Helsinki website you are in the doctoral program and recently defended your dissertation. I hope it went well for you.

Could you help me? I am curious, is there is a relationship between the Prevotellaceae family and in vivo production of Nitric Oxide?

Many thank yous,
Allissa living in Sweden

Resources
1) Pa­tients with Par­kin­son’s dis­ease have clear changes in their gut mi­cro­bi­ota
25.3.2019
https://www.helsinki.fi/en/news/life-science-news/patients-with-parkinsons-disease-have-clear-changes-in-their-gut-microbiota

2) http://www.gutmicrobiotaforhealth.com/en/gut-microbiota-in-parkinsons-disease
27 DEC 2014 Filip Scheperjans



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