Peter was kind enough to respond to my email within 7 minutes. He apologized for no clear answers to give me. Microbes and the fascia/conduit system to propagate tissue is outside of his area of expertise.

He suggested need for tissue samples and perform 3D microscopy to address questions scientifically.

Original email dated v30 fredag den 26 juli 2019

To: Peter Friedl European Onocology researcher
Re: Cancer “Stop Signals”, perhaps a mycologist could help. Fascia is our Stroma.

Lieve Mijnheer Friedl,
I have read some of your Research Papers with Stephanie Alexander.  Thank you for being in Bruce Schonfeld’s documentary “The Secret Life of Fascia, part 1”.  Sue Hitzmann spoke very highly of your work and lecture at The 5th Fascial Research Congress in Berlin last November.

Dr. Tom Findley spoke in 2015 at the Joint Conference on Acupuncture, Oncology and Fascia.  He said, looking for lost keys under the light will not lead to finding the keys.  We look under the light because we can see better, but the keys are somewhere else.

In the same theme, I am writing to you.  You are the researcher / scientist, I am the curious student of fascia and microbes.  If one wants to find the “Stop Signals”, could you please speak to someone who knows about small communities – such as a mycologist, a biologist specializing in mycology, about the nano-environment?

The Extra Cellular Fluid and Stroma is where microbes live, thrive and communicate.  Perhaps a mycologist from Micropia can shed light where there is darkness on cellular behavior as well as microbial behavior.  

Thank you kindly for reading.
Allissa from Iowa, Living in Sweden

CELL, Volume 147, Issue 5, 23 November 2011, Pages 992-1009
“Cancer Invasion and the Microenvironment: Plasticity and Reciprocity”
Cancer cells recapitulate the types and mechanisms of migration used by normal, nontumor cells. They activate the same machineries for changing shape, generating force, and remodeling ECM (Friedl, 2004) as normal cells, but neoplastic cells lack physiological  ‘‘stop  signals’’  immobilizing and anchoring the cells (Cox et al., 2001), which arguably perpetuates neoplastic cell migration.

STROMA – thought from Allissa
Humans are advanced organisms of Stroma like the mycelia of a forest.  Sclerotic fungi vs soft fungi is stroma.  Humans are made up of wandering cells, fixed cells, and fibroblastic cells with different tissue types (loose and dense irregular) with fluid and fibers in between.

A mycologist knows about the forest environment where fungi live, why not use their knowledge and apply it to the human body?

The Naked Scientist discussed Schwann cells in interviews with Professor Alison Lloyd who works at the University College London.  Schwann Cells are Neuroglia which are present in the periphery.  Professor Lloyd states peripheral nerve cell damage can be healed by Schwann cells.  The healing brings back sensation and movement.  

Schwann cells are able to migrate out of a severed nerve across a bridge of tissue.  As they travel, they take the axons they are attached to with them.  Like dragging a broken foot to the hospital, one limp at a time.  Schwann cells NEED a track or a bridge of tissue to travel along.  In Professor Lloyds example, a blood vessel is the surface Schwann cells use as a bridge.

The Stroma type in Professor Lloyd’s example is a blood vessel.  Fascia must be another conduit.   Fascia can be the surface Schwann cells use as a Track or a Bridge for healthy stroma or for cancer stroma which thinks it is unhealed.  

Understanding cellular behavior changes as well as microbial behavior comes from bringing other professions into the cancer lab.  Perhaps a mycologist can be the person to shed light on the communication of microbes such as the mycelia of a forest.

Nerve repair provides clue to cancer spread
26 September 2010

It’s this ephrin signalling that tells the Schwann cells to organise themselves into tracks, as directed by the fibroblasts, so the nerves can regrow, a bit like traffic police using special hand signals to direct cars into different queues on a road.
And, importantly, the scientists found that switching off ephrin signalling meant that Schwann cells couldn’t repair nerve damage, proving that it’s a fundamental part of the process. So these findings tell us something important about nerve repair, which will be useful for researchers working on techniques such as nerve grafts, which could repair damaged nerves after accidents or surgery.
So how is this linked to cancer?
Professor Lloyd thinks that cancer cells may be acting a bit like an unhealed wound, hijacking the signals that normally repair nerves.


Scientists re-grow damaged nerves 
17 August 2015

Professor Alison Lloyd – “And so, I think what our work suggests is that what you want to do is to mimic the real bridge. So, you want to maybe make tubes with blood vessels, either blood vessels themselves or surfaces that mimic what it is about blood vessels that provide a surface for the Schwann cells. But I think it has broader implications for other diseases as well. The way that certain cancers spread within the body, these cells are moving along the surface of other cells. It has been observed that cells such as melanomas and gliomas for example.”

“They’re brain tumours and they’re very, very invasive. That’s the major problem with them but they also seem to be migrating along the surface of blood vessels. So, it’s possible that when these cancer cells are moving and they’re moving along blood vessels, they’re using the same mechanisms that you see following an injury and they’re co-opting this type of behaviour in order to spread. And so again, if we can understand that better then possibly, we can understand better how tumours spread and then maybe do something about it.”

Panel Discussion, OSHER Joint Conference – November 2015
OSHER Center for Integrative Medicine
@36:00 – 37:10 – Dr. Tom Findley
Professor of Physical Medicine and Rehabilitation, Rutgers, New Jersey Medical School, VA New Jersey Health Care System

“Looking for keys under the light….…muscle does not get cancer metastasis very much. So why is it so resistant? Muscle actually makes a small molecular product that you can filter out of a muscle cell culture which will kill tumor cells – so activating muscle may have protective effects elsewhere in the body not just on muscle….”